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Posted: 2025-04-10 03:36:36 UTC
We use a score to evaluate content reliability. This article's score is high enough, and there are no largely false claims identified in this rollup.
We use a score to evaluate content reliability. This article's score is high enough, and there are no largely false claims identified in this rollup.
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2025-04-10 03:36:53 UTC
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Gu et al. discovered that TDP-43 exhibits rhythmic expression and regulates USP13 mRNA splicing, affecting BMAL1 ubiquitination. Its dysfunction disrupts murine circadian rhythms and cognition, linking TDP-43 to circadian-metabolic coupling in neurodegeneration.
TDP-43 rhythmic expression
USP13 mRNA splicing regulation
BMAL1 ubiquitination impact
Circadian rhythm disruption
Cognitive impairment link
Circadian-metabolic coupling in neurodegeneration
TDP-43 dysfunction
Disrupted circadian rhythms
Cognitive impairment