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Posted: 2025-04-12 18:12:14 UTC
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
Status
Last Updated
2025-04-12 18:12:41 UTC
Verified By
Rollup News
Niemann-Pick Type C (NPC), a rare lysosomal disorder affecting cholesterol trafficking, can manifest as psychosis in adults, mimicking treatment-resistant schizophrenia. Studying NPC provides insights into the biological underpinnings of schizophrenia, including neurometabolic dysfunction, disconnectivity, impaired myelination, and subcortical degeneration. Early identification of NPC is crucial as it is a treatable cause of secondary psychosis.
NPC as a model for psychosis
Mimicry of treatment-resistant schizophrenia
Neurometabolic dysfunction insights
White matter disruption and disconnectivity
Clinical implications for diagnosis and treatment
Delayed diagnosis due to motor symptoms mistaken for antipsychotic side effects
Misattribution of impaired vertical saccades to medication effects
Treatment resistance in adult-onset NPC
Diagnostic challenges in differentiating NPC-related psychosis from primary psychotic disorders