Single Mitochondrial DNA Mutation Induces Autism-Like Behavior in Mice

TL;DR;

A study on mice reveals that a single mitochondrial DNA mutation can lead to autism-like behaviors, including social deficits, anxiety, and EEG disruptions, without causing changes in brain anatomy. The mutation results in reduced mitochondrial respiration and increased oxidative stress, particularly in the cortex, suggesting that even mild mitochondrial defects can disrupt high-energy-demand brain circuits and contribute to autism spectrum disorder (ASD).