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Posted: 2025-04-17 19:23:42 UTC
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
Status
Last Updated
2025-04-17 19:23:58 UTC
Verified By
Rollup News
This study investigates how modulating AP-1 in CAR-T cells can create a PD-1+ Tcf1+ stem-like reservoir within tumors, which helps overcome resistance to PD-1 axis blockade.
Modulating AP-1 in CAR-T cells enhances their ability to establish a stem-like reservoir within tumors.
This stem-like reservoir helps CAR-T cells overcome resistance to PD-1 axis blockade.
The findings provide insights into improving CAR-T cell therapy for cancer treatment.
Resistance to PD-1 axis blockade in CAR-T cell therapy
Establishing a long-lasting and effective CAR-T cell response within tumors