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SYSTEM PROCESSING...
Posted: 2025-04-24 04:54:37 UTC
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
This article contains some claims that remain unverified. While much of the content may be accurate, exercise care when relying on this information.
Status
Last Updated
2025-04-24 04:57:24 UTC
Verified By
Rollup News
A study published in the European Heart Journal explores sex-related differences in prosthesis-patient mismatch (PPM) following surgical aortic valve replacement (SAVR) and their impact on long-term outcomes. The research investigates the accuracy of current PPM definitions and the potential benefits of adapting these definitions using Spline-derived predicted effective orifice area indexed (pEOAi) thresholds.
PPM incidence is higher in women when using VARC-3 thresholds and is associated with worse outcomes only in women.
Adapting PPM definition to pEOAi thresholds was associated with worse outcomes in both sexes.
PPM definition should consider higher EOAi thresholds in men than in women.
Refined PPM definition associated with all-cause long-term mortality (p = 0.04) and perioperative mortality also in men (p ≥0.01).
Determining accurate PPM definitions for both sexes.
Understanding the impact of PPM on mortality and cardiovascular outcomes.
Accounting for sex-specific differences in EOAi thresholds.